by ery_admin | May 28, 2015 | article summary
This is a summary of an article we consider recommended reading. Severe infection with Plasmodium falciparum remains a major cause of death in the tropics. It is associated with Run microvascular obstruction resulting from sequestration of red blood cells (RBC’s) containing mature stages of the parasite. The parasitized RBC’s impede the passage of the uninfected red blood cells, which are forced to deform more than usual in their transit through the microcirculation. The relationship between RBC deformability (RBC-D) and disease severity in falciparum malaria was investigated in this study. The RBC-D cheap nba jerseys was measured in 23 patients with severe falciparum malaria (seven of whom subsequently died), 30 patients with uncomplicated malaria, and 17 healthy controls. The RBC-D, measured by ektacytometry, was significantly reduced in severe malaria and was particularly low in all fatal cases. Patients with acute falciparum malaria seem to have less deformable RBC’s than healthy subjects and this rigidity increases with increasing severity of the infection. It showed severely reduced RBC-D (El < 0.21) at a shear stress of 1.7 Pa predicted fatal outcome with a sensitivity of 100% (confidence interval (CI) = 59-100%)) and a specificity of 88% (CI = 61-98%). Since the majority of RBC’s even in severe malaria is Aachen uninfected, this reduction in RBC-D results mainly from changes in the unparasitized RBC’s. Reduced deformability of unparasitized RBC’s in severe malaria may contribute to impaired microcirculatory flow and a fatal outcome in severe falciparum malaria. If reduced RBC-D is a cause rather than an effect of potentially lethal organ dysfunction in severe malaria, then measures to correct this abnormality may save lives....
by ery_admin | May 18, 2015 | article summary
This 5 is a wholesale jerseys summary Multi-Purpose of an cheap jerseys China article we consider as recommended reading. Judith C.A. Cluitmans, Max R. Hardeman, Sip Dinkla, Roland Brock, and Giel J.C.G.M. Bosman During the storage of blood at blood banks, storage lesions of RBC’s can occur; various metabolic, structural and morphologic changes. Blood bank quality guidelines focus on the acceptable extent of these metabolic changes. However, the actual consequences of these changes for RBC survival after transfusion are mostly unknown. The storage-associated morphological changes suggest that alterations in membrane structure are more likely to cause an increase in harmful effects; in this article available data are reviewed on aging-associated and storage-associated alterations in RBC deformability. RBC deformability is a major determinant of RBC survival and the ability to adapt their shape to the dynamic flow conditions plays a key role in the microcirculation. Changes in mean corpuscular hemoglobin concentration (MCHC) occur during storage in Saline, Adenine, Glucose and Manitol solution (SAGM), proteomic and biochemical data suggest oxidation as well as breakdown of structural proteins already in the first weeks of storage. Recent data, obtained by the Lorrca®, did not indicate that the deformability of SAGM-stored RBC’s decreases with storage time, not even after 5 weeks. In contrast, a comparison of fresh RBC’s isolated directly from whole blood with RBC’s in their first week of storage strongly suggests that deformability does already decrease during the three days of processing from blood to blood bag in the blood bank. Functionally relevant molecular changes are likely to become irreversible after 14 to 21 days of storage, because of progressive proteolysis and vesicle formation. It will be...
