Improving the quality of banked blood

Article summary: Improving the quality of banked blood A very interesting article from Duke university on restoring the RBC deformability and reducing endothelium adhesion of banked blood. Banked blood is widely used for blood transfusion to replace lost or malfunctioning red blood cells. Banked blood is known to have a very limited shelf life due to storage lesions. These lesions are actually already induced in the first hours of storage. Normal RBC’s circulate for some 100 days in the human body before being recycled. Banked transfusion RBC’s in contrast are known to have a half-life of only 7 to 10 days. This short half-life and transfusion related complications can be anticipated from the (Lorrca) measured reduction in deformability and increase in endothelial adhesion of the RBC’s. This study shows that storage lesions of the banked RBC (in an animal model) may be reversed, prior to transfusion, by reloading the RBC’s with NO. Interestingly for me as a mechanical engineer the S-nitrosylation also seems to lubricate the RBC’s cytoskeleton. https://www.researchgate.net/publication/279066485_Renitrosylation_of_banked_human_red_blood_cells_improves_deformability_and_reduces_adhesivity Renitrosylation of banked human red blood cells improves deformability and reduces adhesivity. Article in Transfusion · June 2015 Daniel A Riccio, Hongmei Zhu, Matthew W Foster, Brendan Huan, Christina Hofmann, Gregory M Palmer Abstract Transfusion of red blood cells (RBCs) is a frequent health care practice. However, unfavorable consequences may occur from transfusions of stored RBCs and are associated with RBC changes during storage. Loss of S-nitrosohemoglobin (SNO-Hb) and other S-nitrosothiols (SNOs) during storage is implicated as a detriment to transfusion efficacy. It was hypothesized that restoring SNOs within banked RBCs would improve RBC functions relevant to successful transfusion outcomes, namely, increased deformability...

Unique Rheology publication database visualises authors and publications interactively on world map

Rheology Publication Have you ever wanted to see where concentrations Diam of publications or authors can be found in certain – countries or regions? Or which authors are employed by a cell certain Research Institute? Well now you can. RRMechatronics has created Game a visual database of publications, authors and institutes. They are placed on a map cheap nba jerseys and can be easily selected from there. OIn the Rheology cheap nba jerseys section there are more tools und linking researchers and publications. We will fill you in on that next time. Do take a look at: https://portal.rrmechatronics.com/poi/person/map/ Just double Hoy click on the map to zoom in and click on a red dot to see how many publications are linked deformability on the institute.  Click on cheap nfl jerseys the name of the in institute for a list of publications and to see which authors are employed there. Clicking on a publication brings up details and an...

Red blood cell rigidification during cyclosporin therapy

Article summary: Red blood cell rigidification during cyclosporin therapy: a possible early warning signal for adverse reactions. Cyclosporin A (CsA) has become an increasingly popular drug in the immunosuppressive treatment after organ transplantation. A major draw-back associated with prolonged cyclosporin use, however, is the adverse clinical reactions; especially nephrotoxicity. In a previous retrospective study with kidney-transplant patients, immunosuppressive treatment with CsA was found to be associated with impaired red blood cell (RBC) deformability. RBC deformability rigidification plays a role in the early pathogenesis of the adverse nephrotoxic complications frequently associated with this immunosuppressive regimen. The aim of the present study was to evaluate and substantiate a possible causal relationship between the use of CsA and its effect on RBC deformability in a prospective study on non-transplant patients. Blood samples of 12 patients with psoriasis were taken before and after 2, wholesale jerseys 4, 8, 12 and 16 weeks of treatment with CsA (3 – 5 mg/day). RBC deformability, expressed as Elongation Index (EI), was measured Imprimerie with the Laser-assisted Optical Rotational Cell Analyzer (Lorrca®).  A dose – response blood relation could not be established within the small range of CsA doses used in this study. Irrespective of the dose, however, a significant correlation (r = – 0.55; p = …mehr 0.0001) between duration of treatment and decrease in EI was Hacked demonstrated. In vitro incubation of blood 2016 with cyclosporin was not able to reproduce this effect, suggesting that a direct cheap jerseys effect of the drug wholesale nfl jerseys on RBC’s is unlikely. Despite its use in relatively low wholesale mlb jerseys doses, CsA causes a reduction in RBC...

Article summary: Prognostic significance of reduced red blood cell deformability in severe falciparum malaria.

This is a summary of an article we consider recommended reading. Severe infection with Plasmodium falciparum remains a major cause of death in the tropics. It is associated with Run microvascular obstruction resulting from sequestration of red blood cells (RBC’s) containing mature stages of the parasite. The parasitized RBC’s impede the passage of the uninfected red blood cells, which are forced to deform more than usual in their transit through the microcirculation. The relationship between RBC deformability (RBC-D) and disease severity in falciparum malaria was investigated in this study. The RBC-D cheap nba jerseys was measured in 23 patients with severe falciparum malaria (seven of whom subsequently died), 30 patients with uncomplicated malaria, and 17 healthy controls. The RBC-D, measured by ektacytometry, was significantly reduced in severe malaria and was particularly low in all fatal cases. Patients with acute falciparum malaria seem to have less deformable RBC’s than healthy subjects and this rigidity increases with increasing severity of the infection. It showed severely reduced RBC-D (El < 0.21) at a shear stress of 1.7 Pa predicted fatal outcome with a sensitivity of 100% (confidence interval (CI) = 59-100%)) and a specificity of 88% (CI = 61-98%). Since the majority of RBC’s even in severe malaria is Aachen uninfected, this reduction in RBC-D results mainly from changes in the unparasitized RBC’s. Reduced deformability of unparasitized RBC’s in severe malaria may contribute to impaired microcirculatory flow and a fatal outcome in severe falciparum malaria. If reduced RBC-D is a cause rather than an effect of potentially lethal organ dysfunction in severe malaria, then measures to correct this abnormality may save lives....