Red blood cell rigidification during cyclosporin therapy

Article summary: Red blood cell rigidification during cyclosporin therapy: a possible early warning signal for adverse reactions.

Cyclosporin A (CsA) has become an increasingly popular drug in the immunosuppressive treatment after organ transplantation. A major draw-back associated with prolonged cyclosporin use, however, is the adverse clinical reactions; especially nephrotoxicity.

In a previous retrospective study with kidney-transplant patients, immunosuppressive treatment with CsA was found to be associated with impaired red blood cell (RBC) deformability. RBC deformability rigidification plays a role in the early pathogenesis of the adverse nephrotoxic complications frequently associated with this immunosuppressive regimen.

The aim of the present study was to evaluate and substantiate a possible causal relationship between the use of CsA and its effect on RBC deformability in a prospective study on non-transplant patients.

Blood samples of 12 patients with psoriasis were taken before and after 2, wholesale jerseys 4, 8, 12 and 16 weeks of treatment with CsA (3 – 5 mg/day). RBC deformability, expressed as Elongation Index (EI), was measured Imprimerie with the Laser-assisted Optical Rotational Cell Analyzer (Lorrca®).  A dose – response blood relation could not be established within the small range of CsA doses used in this study. Irrespective of the dose, however, a significant correlation (r = – 0.55; p = …mehr 0.0001) between duration of treatment and decrease in EI was Hacked demonstrated. In vitro incubation of blood 2016 with cyclosporin was not able to reproduce this effect, suggesting that a direct cheap jerseys effect of the drug wholesale nfl jerseys on RBC’s is unlikely. Despite its use in relatively low wholesale mlb jerseys doses, CsA causes a reduction in RBC ????? deformability, an effect that increases malaria. during the course of treatment.

The suggestion, based on results of the present study, that red cell rigidification is a useful marker in predicting the early development of CsA nephrotoxicity, i.e., before a measurable loss in renal function (serum creatinine, glomerular filtration rate), needs of course to be validated in more extensive prospective and longitudinal clinical studies.

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